1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3430-3. doi: 10.1016/j.bmcl.2005.05.012.

Abstract

The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.

MeSH terms

  • Carboxylic Acids / pharmacology*
  • Humans
  • Molecular Conformation
  • Molecular Mimicry
  • Protein Binding / drug effects
  • Receptor, Melanocortin, Type 4 / agonists*
  • Receptor, Melanocortin, Type 4 / metabolism
  • Structure-Activity Relationship
  • Tetrahydroisoquinolines / chemistry*
  • Tetrahydronaphthalenes / pharmacology*

Substances

  • Carboxylic Acids
  • MC4R protein, human
  • Receptor, Melanocortin, Type 4
  • Tetrahydroisoquinolines
  • Tetrahydronaphthalenes
  • 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid